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DNA Damage Activates the SAC in an ATM/ATR-Dependent Manner, Independently of the Kinetochore
The DNA damage checkpoint and the spindle assembly checkpoint (SAC) are two important regulatory mechanisms that respond to different lesions. The DNA damage checkpoint detects DNA damage, initiates protein kinase cascades, and inhibits the cell cycle. The SAC relies on kinetochore-dependent assembl...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
Public Library of Science
2008
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2265443/ https://ncbi.nlm.nih.gov/pubmed/18454191 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1000015 |
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