CUX1 transcription factor is required for optimal ATM/ATR-mediated responses to DNA damage

The p110 Cut homeobox 1 (CUX1) transcription factor regulates genes involved in DNA replication and chromosome segregation. Using a genome-wide-approach, we now demonstrate that CUX1 also modulates the constitutive expression of DNA damage response genes, including ones encoding ATM and ATR, as well...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Vadnais, Charles, Davoudi, Sayeh, Afshin, Mojdeh, Harada, Ryoko, Dudley, Rachel, Clermont, Pier-Luc, Drobetsky, Elliot, Nepveu, Alain
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2012
Schlagworte:
Genome Integrity, Repair and Replication
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3378881/
https://ncbi.nlm.nih.gov/pubmed/22319212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks041
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