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Cooperative activation of the ATR checkpoint kinase by TopBP1 and damaged DNA
TopBP1, acting in concert with DNA containing bulky base lesions, stimulates ATR kinase activity under physiologically relevant reaction conditions. Here, we analyze the roles of the three components in ATR activation: DNA, base damage and TopBP1. We show that base adducts caused by a potent carcino...
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| Hlavní autoři: | , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Oxford University Press
2009
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2655664/ https://ncbi.nlm.nih.gov/pubmed/19139065 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn1075 |
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