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Cooperative activation of the ATR checkpoint kinase by TopBP1 and damaged DNA

TopBP1, acting in concert with DNA containing bulky base lesions, stimulates ATR kinase activity under physiologically relevant reaction conditions. Here, we analyze the roles of the three components in ATR activation: DNA, base damage and TopBP1. We show that base adducts caused by a potent carcino...

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Détails bibliographiques
Auteurs principaux: Choi, Jun-Hyuk, Lindsey-Boltz, Laura A., Sancar, Aziz
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2009
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2655664/
https://ncbi.nlm.nih.gov/pubmed/19139065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn1075
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