Llwytho...

Cooperative activation of the ATR checkpoint kinase by TopBP1 and damaged DNA

TopBP1, acting in concert with DNA containing bulky base lesions, stimulates ATR kinase activity under physiologically relevant reaction conditions. Here, we analyze the roles of the three components in ATR activation: DNA, base damage and TopBP1. We show that base adducts caused by a potent carcino...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Choi, Jun-Hyuk, Lindsey-Boltz, Laura A., Sancar, Aziz
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2009
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2655664/
https://ncbi.nlm.nih.gov/pubmed/19139065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn1075
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