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Reconstitution of a human ATR-mediated checkpoint response to damaged DNA
The DNA damage checkpoint response delays cell cycle progression upon DNA damage and prevents genomic instability. Genetic analysis has identified sensor, mediator, signal transducer, and effector components of this global signal transduction pathway. Here we describe an in vitro system with purifie...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2007
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1941640/ https://ncbi.nlm.nih.gov/pubmed/17686975 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0706013104 |
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