Reconstitution of RPA-covered single-stranded DNA-activated ATR-Chk1 signaling

ATR kinase is a critical upstream regulator of the checkpoint response to various forms of DNA damage. Previous studies have shown that ATR is recruited via its binding partner ATR-interacting protein (ATRIP) to replication protein A (RPA)-covered single-stranded DNA (RPA-ssDNA) generated at sites o...

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Main Authors: Choi, Jun-Hyuk, Lindsey-Boltz, Laura A., Kemp, Michael, Mason, Aaron C., Wold, Marc S., Sancar, Aziz
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2010
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2922256/
https://ncbi.nlm.nih.gov/pubmed/20616048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1007856107
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