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Reconstitution of RPA-covered single-stranded DNA-activated ATR-Chk1 signaling
ATR kinase is a critical upstream regulator of the checkpoint response to various forms of DNA damage. Previous studies have shown that ATR is recruited via its binding partner ATR-interacting protein (ATRIP) to replication protein A (RPA)-covered single-stranded DNA (RPA-ssDNA) generated at sites o...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2922256/ https://ncbi.nlm.nih.gov/pubmed/20616048 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1007856107 |
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