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Reconstitution of a human ATR-mediated checkpoint response to damaged DNA

The DNA damage checkpoint response delays cell cycle progression upon DNA damage and prevents genomic instability. Genetic analysis has identified sensor, mediator, signal transducer, and effector components of this global signal transduction pathway. Here we describe an in vitro system with purifie...

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Bibliografski detalji
Glavni autori: Choi, Jun-Hyuk, Lindsey-Boltz, Laura A., Sancar, Aziz
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2007
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1941640/
https://ncbi.nlm.nih.gov/pubmed/17686975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0706013104
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