DNA-PK Phosphorylation of RPA32 Ser4/Ser8 Regulates Replication Stress Checkpoint Activation, Fork Restart, Homologous Recombination and Mitotic Catastrophe

Genotoxins and other factors cause replication stress that activate the DNA damage response (DDR), comprising checkpoint and repair systems. The DDR suppresses cancer by promoting genome stability, and it regulates tumor resistance to chemo- and radiotherapy. Three members of the phosphatidylinosito...

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Hauptverfasser: Ashley, Amanda K., Shrivastav, Meena, Nie, Jingyi, Amerin, Courtney, Troksa, Kyle, Glanzer, Jason G., Liu, Shengqin, Opiyo, Stephen O., Dimitrova, Diana D., Le, Phuong, Sishc, Brock, Bailey, Susan M., Oakley, Greg G., Nickoloff, Jac A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4135522/
https://ncbi.nlm.nih.gov/pubmed/24819595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2014.04.008
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