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Chk1 phosphorylation of Metnase/SETMAR at Ser495 enhances DNA repair but decreases replication fork restart

Chk1 both arrests replication forks and enhances repair of DNA damage by phosphorylation of downstream effectors. While there has been a distinguished effort in identifying effectors of Chk1 activity, there are still mechanisms of its activities that are yet to be identified. Metnase/SETMAR is a SET...

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מידע ביבליוגרפי
Main Authors: Hromas, Robert, Williamson, Elizabeth, Fnu, Sheema, Lee, Young-Ju, Park, Su-Jung, Beck, Brian D., You, Jin-Sam, Laitao, Andrei, Nickoloff, Jac A., Lee, Suk-Hee
פורמט: Artigo
שפה:Inglês
יצא לאור: 2012
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3963179/
https://ncbi.nlm.nih.gov/pubmed/22231448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2011.586
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