Novel method for site-specific induction of oxidative DNA damage reveals differences in recruitment of repair proteins to heterochromatin and euchromatin

Reactive oxygen species (ROS)-induced DNA damage is repaired by the base excision repair pathway. However, the effect of chromatin structure on BER protein recruitment to DNA damage sites in living cells is poorly understood. To address this problem, we developed a method to specifically produce ROS...

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Detalhes bibliográficos
Main Authors: Lan, Li, Nakajima, Satoshi, Wei, Leizhen, Sun, Luxi, Hsieh, Ching-Lung, Sobol, Robert W., Bruchez, Marcel, Van Houten, Bennett, Yasui, Akira, Levine, Arthur S.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3936713/
https://ncbi.nlm.nih.gov/pubmed/24293652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt1233
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