WRN is recruited to damaged telomeres via its RQC domain and tankyrase1-mediated poly-ADP-ribosylation of TRF1

Werner syndrome (WS) is a progeroid-like syndrome caused by WRN gene mutations. WS cells exhibit shorter telomere length compared to normal cells, but it is not fully understood how WRN deficiency leads directly to telomere dysfunction. By generating localized telomere-specific DNA damage in a real-...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Sun, Luxi, Nakajima, Satoshi, Teng, Yaqun, Chen, Hao, Yang, Lu, Chen, Xiukai, Gao, Boya, Levine, Arthur S., Lan, Li
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5397154/
https://ncbi.nlm.nih.gov/pubmed/28158503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx065
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