WRN is recruited to damaged telomeres via its RQC domain and tankyrase1-mediated poly-ADP-ribosylation of TRF1

Werner syndrome (WS) is a progeroid-like syndrome caused by WRN gene mutations. WS cells exhibit shorter telomere length compared to normal cells, but it is not fully understood how WRN deficiency leads directly to telomere dysfunction. By generating localized telomere-specific DNA damage in a real-...

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Bibliographische Detailangaben
Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Sun, Luxi, Nakajima, Satoshi, Teng, Yaqun, Chen, Hao, Yang, Lu, Chen, Xiukai, Gao, Boya, Levine, Arthur S., Lan, Li
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2017
Schlagworte:
Genome Integrity, Repair and Replication
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5397154/
https://ncbi.nlm.nih.gov/pubmed/28158503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx065
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