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Strand exchange of telomeric DNA catalyzed by the Werner syndrome protein (WRN) is specifically stimulated by TRF2

Werner syndrome (WS), caused by loss of function of the RecQ helicase WRN, is a hereditary disease characterized by premature aging and elevated cancer incidence. WRN has DNA binding, exonuclease, ATPase, helicase and strand annealing activities, suggesting possible roles in recombination-related pr...

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Detalhes bibliográficos
Main Authors: Edwards, Deanna N., Orren, David K., Machwe, Amrita
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4081078/
https://ncbi.nlm.nih.gov/pubmed/24880691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku454
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