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Telomeric protein TRF2 protects Holliday junctions with telomeric arms from displacement by the Werner syndrome helicase

WRN protein loss causes Werner syndrome (WS), which is characterized by premature aging as well as genomic and telomeric instability. WRN prevents telomere loss, but the telomeric protein complex must regulate WRN activities to prevent aberrant telomere processing. Telomere-binding TRF2 protein inhi...

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Autors principals: Nora, Gerald J., Buncher, Noah A., Opresko, Patricia L.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2896529/
https://ncbi.nlm.nih.gov/pubmed/20215438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq144
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