Telomere proteins POT1, TRF1 and TRF2 augment long-patch base excision repair in vitro

Human telomeres consist of multiple tandem hexameric repeats, each containing a guanine triplet. Guanosine-rich clusters are highly susceptible to oxidative base damage, necessitating base excision repair (BER). Previous demonstration of enhanced strand displacement synthesis by the BER component DN...

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Detalhes bibliográficos
Main Authors: Miller, Adam S, Balakrishnan, Lata, Buncher, Noah A, Opresko, Patricia L, Bambara, Robert A
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2012
Assuntos:
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3323798/
https://ncbi.nlm.nih.gov/pubmed/22336916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.11.5.19483
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