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POT1-TPP1 Regulates Telomeric Overhang Structural Dynamics
Human telomeres possess a single-stranded DNA (ssDNA) overhang of TTAGGG repeats, which can self-fold into a G-quadruplex structure. POT1 binds specifically to the telomeric overhang and partners with TPP1 to regulate telomere lengthening and capping, although the mechanism remains elusive. Here, we...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4109716/ https://ncbi.nlm.nih.gov/pubmed/22981946 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2012.08.018 |
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