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Telomeric overhang length determines structural dynamics and accessibility to telomerase and ALT associated proteins
The G-rich single stranded DNA at the 3′ end of human telomeres can self-fold into G-quaduplex (GQ). However, telomere lengthening by telomerase or the recombination-based alternative lengthening of telomere (ALT) mechanism requires protein loading on the overhang. Using single molecule fluorescence...
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| Главные авторы: | , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4067947/ https://ncbi.nlm.nih.gov/pubmed/24836024 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2014.03.013 |
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