Telomeric overhang length determines structural dynamics and accessibility to telomerase and ALT associated proteins

The G-rich single stranded DNA at the 3′ end of human telomeres can self-fold into G-quaduplex (GQ). However, telomere lengthening by telomerase or the recombination-based alternative lengthening of telomere (ALT) mechanism requires protein loading on the overhang. Using single molecule fluorescence...

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Bibliographische Detailangaben
Hauptverfasser: Hwang, Helen, Kreig, Alex, Calvert, Jacob, Lormand, Justin, Kwon, Yongho, Daley, James M., Sung, Patrick, Opresko, Patricia L., Myong, Sua
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4067947/
https://ncbi.nlm.nih.gov/pubmed/24836024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2014.03.013
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