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Telomere Protection by TPP1 Is Mediated by POT1a and POT1b
Mammalian telomeres are protected by the shelterin complex, which contains single-stranded telomeric DNA binding proteins (POT1a and POT1b in rodents, POT1 in other mammals). Mouse POT1a prevents the activation of the ATR kinase and contributes to the repression of the nonhomologous end-joining path...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Society for Microbiology (ASM)
2010
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2815557/ https://ncbi.nlm.nih.gov/pubmed/19995905 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01498-09 |
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