Telomere protection by TPP1/POT1 requires tethering to TIN2

To prevent ATR activation, telomeres deploy the single-stranded DNA binding activity of TPP1/POT1a. POT1a blocks the binding of RPA to telomeres, suggesting that ATR is repressed through RPA exclusion. However, comparison on the DNA binding affinities and abundance of TPP1/POT1a and RPA indicates th...

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Bibliografiske detaljer
Main Authors: Takai, Kaori K., Kibe, Tatsuya, Donigian, Jill R., Frescas, David, de Lange, Titia
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3222871/
https://ncbi.nlm.nih.gov/pubmed/22099311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.08.043
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