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Telomere protection by TPP1/POT1 requires tethering to TIN2
To prevent ATR activation, telomeres deploy the single-stranded DNA binding activity of TPP1/POT1a. POT1a blocks the binding of RPA to telomeres, suggesting that ATR is repressed through RPA exclusion. However, comparison on the DNA binding affinities and abundance of TPP1/POT1a and RPA indicates th...
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| Hlavní autoři: | , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2011
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3222871/ https://ncbi.nlm.nih.gov/pubmed/22099311 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.08.043 |
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