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TPP1 blocks an ATR-mediated resection mechanism at telomeres
The regulation of 5’ end resection at DSBs and telomeres prevents genome instability. DSB resection is positively and negatively regulated by ATM signaling through CtIP/MRN and 53BP1-bound Rif1, respectively. Similarly, telomeres lacking TRF2 undergo ATM-controlled CtIP-dependent hyper-resection whe...
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| Publicado en: | Mol Cell |
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| Autores principales: | , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2016
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4724337/ https://ncbi.nlm.nih.gov/pubmed/26778124 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.12.016 |
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