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TPP1 blocks an ATR-mediated resection mechanism at telomeres

The regulation of 5’ end resection at DSBs and telomeres prevents genome instability. DSB resection is positively and negatively regulated by ATM signaling through CtIP/MRN and 53BP1-bound Rif1, respectively. Similarly, telomeres lacking TRF2 undergo ATM-controlled CtIP-dependent hyper-resection whe...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Mol Cell
Egile Nagusiak: Kibe, Tatsuya, Zimmermann, Michal, de Lange, Titia
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2016
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4724337/
https://ncbi.nlm.nih.gov/pubmed/26778124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.12.016
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