TRF1 and TRF2 use different mechanisms to find telomeric DNA but share a novel mechanism to search for protein partners at telomeres

Human telomeres are maintained by the shelterin protein complex in which TRF1 and TRF2 bind directly to duplex telomeric DNA. How these proteins find telomeric sequences among a genome of billions of base pairs and how they find protein partners to form the shelterin complex remains uncertain. Using...

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Autors principals: Lin, Jiangguo, Countryman, Preston, Buncher, Noah, Kaur, Parminder, E, Longjiang, Zhang, Yiyun, Gibson, Greg, You, Changjiang, Watkins, Simon C., Piehler, Jacob, Opresko, Patricia L., Kad, Neil M., Wang, Hong
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2014
Matèries:
Molecular Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3936710/
https://ncbi.nlm.nih.gov/pubmed/24271387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt1132
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