TRF1 and TRF2 use different mechanisms to find telomeric DNA but share a novel mechanism to search for protein partners at telomeres

Human telomeres are maintained by the shelterin protein complex in which TRF1 and TRF2 bind directly to duplex telomeric DNA. How these proteins find telomeric sequences among a genome of billions of base pairs and how they find protein partners to form the shelterin complex remains uncertain. Using...

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Detalhes bibliográficos
Main Authors: Lin, Jiangguo, Countryman, Preston, Buncher, Noah, Kaur, Parminder, E, Longjiang, Zhang, Yiyun, Gibson, Greg, You, Changjiang, Watkins, Simon C., Piehler, Jacob, Opresko, Patricia L., Kad, Neil M., Wang, Hong
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
Molecular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3936710/
https://ncbi.nlm.nih.gov/pubmed/24271387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt1132
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