Telomeric protein TRF2 protects Holliday junctions with telomeric arms from displacement by the Werner syndrome helicase

WRN protein loss causes Werner syndrome (WS), which is characterized by premature aging as well as genomic and telomeric instability. WRN prevents telomere loss, but the telomeric protein complex must regulate WRN activities to prevent aberrant telomere processing. Telomere-binding TRF2 protein inhi...

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Bibliographic Details
Main Authors:	Nora, Gerald J., Buncher, Noah A., Opresko, Patricia L.
Format:	Artigo
Language:	Inglês
Published:	Oxford University Press 2010
Subjects:	Genome Integrity, Repair and Replication
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2896529/ https://ncbi.nlm.nih.gov/pubmed/20215438 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq144
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Telomeric protein TRF2 protects Holliday junctions with telomeric arms from displacement by the Werner syndrome helicase

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