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Length-dependent degradation of single-stranded 3' ends by the Werner syndrome protein (WRN): implications for spatial orientation and coordinated 3' to 5' movement of its ATPase/helicase and exonuclease domains
BACKGROUND: The cancer-prone and accelerated aging disease Werner syndrome is caused by loss of function of the WRN gene product that possesses ATPase, 3' to 5' helicase and 3' to 5' exonuclease activities. Although WRN has been most prominently suggested to function in telomere...
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Autori principali: | , , |
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Natura: | Artigo |
Lingua: | Inglês |
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BioMed Central
2006
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Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1435914/ https://ncbi.nlm.nih.gov/pubmed/16503984 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2199-7-6 |
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