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DNA secondary structure of the released strand stimulates WRN helicase action on forked duplexes without coordinate action of WRN exonuclease

Werner syndrome (WS) is an autosomal recessive premature aging disorder characterized by aging-related phenotypes and genomic instability. WS is caused by mutations in a gene encoding a nuclear protein, Werner syndrome protein (WRN), a member of the RecQ helicase family, that interestingly possesses...

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Bibliografske podrobnosti
izdano v:Biochem Biophys Res Commun
Main Authors: Ahn, Byungchan, Bohr, Vilhelm A.
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4586246/
https://ncbi.nlm.nih.gov/pubmed/21763283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2011.06.184
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