WRN Exonuclease activity is blocked by specific oxidatively induced base lesions positioned in either DNA strand

Werner syndrome (WS) is a premature aging disorder caused by mutations in the WS gene (WRN). Although WRN has been suggested to play an important role in DNA metabolic pathways, such as recombination, replication and repair, its precise role still remains to be determined. WRN possesses ATPase, heli...

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Bibliografski detalji
Glavni autori: Bukowy, Zuzanna, Harrigan, Jeanine A., Ramsden, Dale A., Tudek, Barbara, Bohr, Vilhelm A., Stevnsner, Tinna
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2008
Teme:
Molecular Biology
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2528166/
https://ncbi.nlm.nih.gov/pubmed/18658245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn468
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