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WRN exonuclease activity is blocked by DNA termini harboring 3' obstructive groups

Reactive oxygen species, generated either by cellular respiration or upon exposure to environmental agents such as ionizing radiation (IR), attack DNA to form a variety of oxidized base and sugar modifications. Accumulation of oxidative DNA damage has been associated with age-related disease as well...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Harrigan, Jeanine A., Fan, Jinshui, Momand, Jamil, Perrino, Fred W., Bohr, Vilhelm A., Wilson, David M.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2006
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC1920796/
https://ncbi.nlm.nih.gov/pubmed/17224176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mad.2006.12.005
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