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WRN exonuclease activity is blocked by DNA termini harboring 3' obstructive groups

Reactive oxygen species, generated either by cellular respiration or upon exposure to environmental agents such as ionizing radiation (IR), attack DNA to form a variety of oxidized base and sugar modifications. Accumulation of oxidative DNA damage has been associated with age-related disease as well...

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Detalhes bibliográficos
Main Authors: Harrigan, Jeanine A., Fan, Jinshui, Momand, Jamil, Perrino, Fred W., Bohr, Vilhelm A., Wilson, David M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1920796/
https://ncbi.nlm.nih.gov/pubmed/17224176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mad.2006.12.005
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