Poly(ADP-ribose) polymerase 1 regulates both the exonuclease and helicase activities of the Werner syndrome protein

Werner syndrome (WS) is a genetic premature aging disorder in which patients appear much older than their chronological age. The gene mutated in WS encodes a nuclear protein (WRN) which possesses 3′–5′ exonuclease and ATPase-dependent 3′–5′ helicase activities. The genomic instability associated wit...

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Hlavní autoři: von Kobbe, Cayetano, Harrigan, Jeanine A., Schreiber, Valérie, Stiegler, Patrick, Piotrowski, Jason, Dawut, Lale, Bohr, Vilhelm A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2004
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC506806/
https://ncbi.nlm.nih.gov/pubmed/15292449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh721
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