Poly(ADP-ribose) polymerase 1 regulates both the exonuclease and helicase activities of the Werner syndrome protein

Werner syndrome (WS) is a genetic premature aging disorder in which patients appear much older than their chronological age. The gene mutated in WS encodes a nuclear protein (WRN) which possesses 3′–5′ exonuclease and ATPase-dependent 3′–5′ helicase activities. The genomic instability associated wit...

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Publié dans:	Nucleic Acids Res
Auteurs principaux:	von Kobbe, Cayetano, Harrigan, Jeanine A., Schreiber, Valérie, Stiegler, Patrick, Piotrowski, Jason, Dawut, Lale, Bohr, Vilhelm A.
Format:	Artigo
Langue:	Inglês
Publié:	Oxford University Press 2004
Sujets:	Articles
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC506806/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15292449/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkh721
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