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Poly(ADP-ribose) polymerase 1 regulates both the exonuclease and helicase activities of the Werner syndrome protein
Werner syndrome (WS) is a genetic premature aging disorder in which patients appear much older than their chronological age. The gene mutated in WS encodes a nuclear protein (WRN) which possesses 3′–5′ exonuclease and ATPase-dependent 3′–5′ helicase activities. The genomic instability associated wit...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC506806/ https://ncbi.nlm.nih.gov/pubmed/15292449 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh721 |
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