WRN exonuclease activity is blocked by DNA termini harboring 3' obstructive groups

Reactive oxygen species, generated either by cellular respiration or upon exposure to environmental agents such as ionizing radiation (IR), attack DNA to form a variety of oxidized base and sugar modifications. Accumulation of oxidative DNA damage has been associated with age-related disease as well...

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Autores principales: Harrigan, Jeanine A., Fan, Jinshui, Momand, Jamil, Perrino, Fred W., Bohr, Vilhelm A., Wilson, David M.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2006
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1920796/
https://ncbi.nlm.nih.gov/pubmed/17224176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mad.2006.12.005
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