טוען...
Selective blockage of the 3′→5′ exonuclease activity of WRN protein by certain oxidative modifications and bulky lesions in DNA
Individuals with mutations in the WRN gene suffer from Werner syndrome, a disease with early onset of many characteristics of normal aging. The WRN protein (WRNp) functions in DNA metabolism, as the purified polypeptide has both 3′→5′ helicase and 3′→5′ exonuclease activities. In this study, we have...
שמור ב:
| Main Authors: | , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
Oxford University Press
2000
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC102646/ https://ncbi.nlm.nih.gov/pubmed/10908333 |
| תגים: |
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