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Selective blockage of the 3′→5′ exonuclease activity of WRN protein by certain oxidative modifications and bulky lesions in DNA

Individuals with mutations in the WRN gene suffer from Werner syndrome, a disease with early onset of many characteristics of normal aging. The WRN protein (WRNp) functions in DNA metabolism, as the purified polypeptide has both 3′→5′ helicase and 3′→5′ exonuclease activities. In this study, we have...

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Bibliographische Detailangaben
Hauptverfasser: Machwe, Amrita, Ganunis, Ruth, Bohr, Vilhelm A., Orren, David K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2000
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC102646/
https://ncbi.nlm.nih.gov/pubmed/10908333
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