Selective blockage of the 3′→5′ exonuclease activity of WRN protein by certain oxidative modifications and bulky lesions in DNA

Individuals with mutations in the WRN gene suffer from Werner syndrome, a disease with early onset of many characteristics of normal aging. The WRN protein (WRNp) functions in DNA metabolism, as the purified polypeptide has both 3′→5′ helicase and 3′→5′ exonuclease activities. In this study, we have...

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Pubblicato in:	Nucleic Acids Res
Autori principali:	Machwe, Amrita, Ganunis, Ruth, Bohr, Vilhelm A., Orren, David K.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Oxford University Press 2000
Soggetti:	Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC102646/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10908333/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/28.14.2762
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