Selective blockage of the 3′→5′ exonuclease activity of WRN protein by certain oxidative modifications and bulky lesions in DNA

Individuals with mutations in the WRN gene suffer from Werner syndrome, a disease with early onset of many characteristics of normal aging. The WRN protein (WRNp) functions in DNA metabolism, as the purified polypeptide has both 3′→5′ helicase and 3′→5′ exonuclease activities. In this study, we have...

ver descrição completa

Detalhes bibliográficos

Publicado no:	Nucleic Acids Res
Principais autores:	Machwe, Amrita, Ganunis, Ruth, Bohr, Vilhelm A., Orren, David K.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Oxford University Press 2000
Assuntos:	Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC102646/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10908333/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/28.14.2762
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!