WRN Exonuclease activity is blocked by specific oxidatively induced base lesions positioned in either DNA strand

Werner syndrome (WS) is a premature aging disorder caused by mutations in the WS gene (WRN). Although WRN has been suggested to play an important role in DNA metabolic pathways, such as recombination, replication and repair, its precise role still remains to be determined. WRN possesses ATPase, heli...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Bukowy, Zuzanna, Harrigan, Jeanine A., Ramsden, Dale A., Tudek, Barbara, Bohr, Vilhelm A., Stevnsner, Tinna
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Oxford University Press 2008
Aiheet:
Molecular Biology
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2528166/
https://ncbi.nlm.nih.gov/pubmed/18658245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn468
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