WRN Exonuclease activity is blocked by specific oxidatively induced base lesions positioned in either DNA strand

Werner syndrome (WS) is a premature aging disorder caused by mutations in the WS gene (WRN). Although WRN has been suggested to play an important role in DNA metabolic pathways, such as recombination, replication and repair, its precise role still remains to be determined. WRN possesses ATPase, heli...

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Autori principali: Bukowy, Zuzanna, Harrigan, Jeanine A., Ramsden, Dale A., Tudek, Barbara, Bohr, Vilhelm A., Stevnsner, Tinna
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2008
Soggetti:
Molecular Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2528166/
https://ncbi.nlm.nih.gov/pubmed/18658245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn468
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