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Mechanism of Werner DNA Helicase: POT1 and RPA Stimulates WRN to Unwind beyond Gaps in the Translocating Strand

WRN belongs to the RecQ family of DNA helicases and it plays a role in recombination, replication, telomere maintenance and long-patch base excision repair. Here, we demonstrate that WRN efficiently unwinds DNA substrates containing a 1-nucleotide gap in the translocating DNA strand, but when the ga...

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Autors principals: Ahn, Byungchan, Lee, Jae Wan, Jung, Hana, Beck, Gad, Bohr, Vilhelm A.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2650403/
https://ncbi.nlm.nih.gov/pubmed/19262689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0004673
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