Functional Subdomain in the Ankyrin Domain of Tankyrase 1 Required for Poly(ADP-Ribosyl)ation of TRF1 and Telomere Elongation

In human cells, telomere elongation by telomerase is repressed in cis by the telomeric protein TRF1. Tankyrase 1 binds TRF1 via its ankyrin domain and poly(ADP-ribosyl)ates it. Overexpression of tankyrase 1 in telomerase-positive cells releases TRF1 from telomeres, resulting in telomere elongation....

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Seimiya, Hiroyuki, Muramatsu, Yukiko, Smith, Susan, Tsuruo, Takashi
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 2004
Assuntos:	DNA Dynamics and Chromosome Structure
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC350561/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14966275/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.24.5.1944-1955.2004
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