Functional Subdomain in the Ankyrin Domain of Tankyrase 1 Required for Poly(ADP-Ribosyl)ation of TRF1 and Telomere Elongation

In human cells, telomere elongation by telomerase is repressed in cis by the telomeric protein TRF1. Tankyrase 1 binds TRF1 via its ankyrin domain and poly(ADP-ribosyl)ates it. Overexpression of tankyrase 1 in telomerase-positive cells releases TRF1 from telomeres, resulting in telomere elongation....

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Cell Biol
Prif Awduron: Seimiya, Hiroyuki, Muramatsu, Yukiko, Smith, Susan, Tsuruo, Takashi
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Taylor & Francis 2004
Pynciau:
DNA Dynamics and Chromosome Structure
Mynediad Ar-lein:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC350561/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14966275/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.24.5.1944-1955.2004
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