Functional Subdomain in the Ankyrin Domain of Tankyrase 1 Required for Poly(ADP-Ribosyl)ation of TRF1 and Telomere Elongation

In human cells, telomere elongation by telomerase is repressed in cis by the telomeric protein TRF1. Tankyrase 1 binds TRF1 via its ankyrin domain and poly(ADP-ribosyl)ates it. Overexpression of tankyrase 1 in telomerase-positive cells releases TRF1 from telomeres, resulting in telomere elongation....

Täydet tiedot

Bibliografiset tiedot

Julkaisussa:	Mol Cell Biol
Päätekijät:	Seimiya, Hiroyuki, Muramatsu, Yukiko, Smith, Susan, Tsuruo, Takashi
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	Taylor & Francis 2004
Aiheet:	DNA Dynamics and Chromosome Structure
Linkit:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC350561/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14966275/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.24.5.1944-1955.2004
Tagit:	Lisää tagi Ei tageja, Lisää ensimmäinen tagi!