Tankyrase1-mediated poly(ADP-ribosyl)ation of TRF1 maintains cell survival after telomeric DNA damage

Oxidative DNA damage triggers telomere erosion and cellular senescence. However, how repair is initiated at telomeres is largely unknown. Here, we found unlike PARP1-mediated Poly-ADP-Ribosylation (PARylation) at genomic damage sites, PARylation at telomeres is mainly dependent on tankyrase1 (TNKS1)...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:Nucleic Acids Res
Main Authors: Yang, Lu, Sun, Luxi, Teng, Yaqun, Chen, Hao, Gao, Ying, Levine, Arthur S., Nakajima, Satoshi, Lan, Li
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2017
Teme:
Genome Integrity, Repair and Replication
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5397190/
https://ncbi.nlm.nih.gov/pubmed/28160604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx083
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki