Tankyrase1-mediated poly(ADP-ribosyl)ation of TRF1 maintains cell survival after telomeric DNA damage

Oxidative DNA damage triggers telomere erosion and cellular senescence. However, how repair is initiated at telomeres is largely unknown. Here, we found unlike PARP1-mediated Poly-ADP-Ribosylation (PARylation) at genomic damage sites, PARylation at telomeres is mainly dependent on tankyrase1 (TNKS1)...

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書目詳細資料
發表在:Nucleic Acids Res
Main Authors: Yang, Lu, Sun, Luxi, Teng, Yaqun, Chen, Hao, Gao, Ying, Levine, Arthur S., Nakajima, Satoshi, Lan, Li
格式: Artigo
語言:Inglês
出版: Oxford University Press 2017
主題:
Genome Integrity, Repair and Replication
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5397190/
https://ncbi.nlm.nih.gov/pubmed/28160604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx083
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