Tankyrase1-mediated poly(ADP-ribosyl)ation of TRF1 maintains cell survival after telomeric DNA damage

Oxidative DNA damage triggers telomere erosion and cellular senescence. However, how repair is initiated at telomeres is largely unknown. Here, we found unlike PARP1-mediated Poly-ADP-Ribosylation (PARylation) at genomic damage sites, PARylation at telomeres is mainly dependent on tankyrase1 (TNKS1)...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Yang, Lu, Sun, Luxi, Teng, Yaqun, Chen, Hao, Gao, Ying, Levine, Arthur S., Nakajima, Satoshi, Lan, Li
Format: Artigo
Language:Inglês
Published: Oxford University Press 2017
Subjects:
Genome Integrity, Repair and Replication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5397190/
https://ncbi.nlm.nih.gov/pubmed/28160604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx083
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