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Differential Repair Protein Recruitment at Sites of Clustered and Isolated DNA Double-Strand Breaks Produced by High-Energy Heavy Ions

DNA double-strand break (DSB) repair is crucial to maintain genomic stability. The fidelity of the repair depends on the complexity of the lesion, with clustered DSBs being more difficult to repair than isolated breaks. Using live cell imaging of heavy ion tracks produced at a high-energy particle a...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Jakob, Burkhard, Dubiak-Szepietowska, Monika, Janiel, Ellen, Schmidt, Alina, Durante, Marco, Taucher-Scholz, Gisela
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6989695/
https://ncbi.nlm.nih.gov/pubmed/31996740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-58084-6
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