Acetylation of 53BP1 dictates the DNA double strand break repair pathway

P53-binding protein 1 (53BP1) plays critical roles in DNA double strand break (DSB) repair by promoting non-homologous end joining (NHEJ), and loss of 53BP1 abolishes PARPi sensitivity in BRCA1-deficient cells by restoring homologous recombination (HR). 53BP1 is one of the proteins initially recruit...

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Bibliografiska uppgifter
I publikationen:Nucleic Acids Res
Huvudupphovsmän: Guo, Xiang, Bai, Yongtai, Zhao, Meimei, Zhou, Mei, Shen, Qinjian, Yun, Cai-Hong, Zhang, Hongquan, Zhu, Wei-Guo, Wang, Jiadong
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2018
Ämnen:
Genome Integrity, Repair and Replication
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5778472/
https://ncbi.nlm.nih.gov/pubmed/29190394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx1208
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