IRF3 promotes adipose inflammation and insulin resistance and represses browning

The chronic inflammatory state that accompanies obesity is a major contributor to insulin resistance and other dysfunctional adaptations in adipose tissue. Cellular and secreted factors promote the inflammatory milieu of obesity, but the transcriptional pathways that drive these processes are not we...

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Bibliographic Details
Published in:J Clin Invest
Main Authors: Kumari, Manju, Wang, Xun, Lantier, Louise, Lyubetskaya, Anna, Eguchi, Jun, Kang, Sona, Tenen, Danielle, Roh, Hyun Cheol, Kong, Xingxing, Kazak, Lawrence, Ahmad, Rasheed, Rosen, Evan D.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2016
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4966307/
https://ncbi.nlm.nih.gov/pubmed/27400129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI86080
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