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IRF3 promotes adipose inflammation and insulin resistance and represses browning

The chronic inflammatory state that accompanies obesity is a major contributor to insulin resistance and other dysfunctional adaptations in adipose tissue. Cellular and secreted factors promote the inflammatory milieu of obesity, but the transcriptional pathways that drive these processes are not we...

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Библиографические подробности
Опубликовано в: :J Clin Invest
Главные авторы: Kumari, Manju, Wang, Xun, Lantier, Louise, Lyubetskaya, Anna, Eguchi, Jun, Kang, Sona, Tenen, Danielle, Roh, Hyun Cheol, Kong, Xingxing, Kazak, Lawrence, Ahmad, Rasheed, Rosen, Evan D.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Clinical Investigation 2016
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4966307/
https://ncbi.nlm.nih.gov/pubmed/27400129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI86080
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