Brown adipose tissue controls skeletal muscle function via the secretion of myostatin

Skeletal muscle and brown adipose tissue (BAT) are functionally linked, as exercise increases browning via secretion of myokines. It is unknown whether BAT affects muscle function. Here, we find that loss of the transcription factor IRF4 in BAT (BATI4KO) reduces exercise capacity, mitochondrial func...

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Detalhes bibliográficos
Publicado no:Cell Metab
Main Authors: Kong, Xingxing, Yao, Ting, Zhou, Peng, Kazak, Lawrence, Tenen, Danielle, Lyubetskaya, Anna, Dawes, Brian A., Tsai, Linus, Kahn, Barbara B., Spiegelman, Bruce M., Liu, Tiemin, Rosen, Evan D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6170693/
https://ncbi.nlm.nih.gov/pubmed/30078553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2018.07.004
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