Dnmt3a is an epigenetic mediator of adipose insulin resistance

Insulin resistance results from an intricate interaction between genetic make-up and environment, and thus may be orchestrated by epigenetic mechanisms like DNA methylation. Here, we demonstrate that DNA methyltransferase 3a (Dnmt3a) is both necessary and sufficient to mediate insulin resistance in...

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Veröffentlicht in:eLife
Hauptverfasser: You, Dongjoo, Nilsson, Emma, Tenen, Danielle E, Lyubetskaya, Anna, Lo, James C, Jiang, Rencong, Deng, Jasmine, Dawes, Brian A, Vaag, Allan, Ling, Charlotte, Rosen, Evan D, Kang, Sona
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2017
Schlagworte:
Cell Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5730374/
https://ncbi.nlm.nih.gov/pubmed/29091029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.30766
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