Dnmt3a is an epigenetic mediator of adipose insulin resistance

Insulin resistance results from an intricate interaction between genetic make-up and environment, and thus may be orchestrated by epigenetic mechanisms like DNA methylation. Here, we demonstrate that DNA methyltransferase 3a (Dnmt3a) is both necessary and sufficient to mediate insulin resistance in...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: You, Dongjoo, Nilsson, Emma, Tenen, Danielle E, Lyubetskaya, Anna, Lo, James C, Jiang, Rencong, Deng, Jasmine, Dawes, Brian A, Vaag, Allan, Ling, Charlotte, Rosen, Evan D, Kang, Sona
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5730374/
https://ncbi.nlm.nih.gov/pubmed/29091029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.30766
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