Dnmt3a is an epigenetic mediator of adipose insulin resistance

Insulin resistance results from an intricate interaction between genetic make-up and environment, and thus may be orchestrated by epigenetic mechanisms like DNA methylation. Here, we demonstrate that DNA methyltransferase 3a (Dnmt3a) is both necessary and sufficient to mediate insulin resistance in...

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Bibliografische gegevens
Gepubliceerd in:eLife
Hoofdauteurs: You, Dongjoo, Nilsson, Emma, Tenen, Danielle E, Lyubetskaya, Anna, Lo, James C, Jiang, Rencong, Deng, Jasmine, Dawes, Brian A, Vaag, Allan, Ling, Charlotte, Rosen, Evan D, Kang, Sona
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: eLife Sciences Publications, Ltd 2017
Onderwerpen:
Cell Biology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5730374/
https://ncbi.nlm.nih.gov/pubmed/29091029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.30766
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