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Tumor-derived PTHrP Triggers Adipose Tissue Browning and Cancer Cachexia

SUMMARY: Cachexia is a wasting disorder of adipose and skeletal muscle tissues that leads to profound weight loss and frailty. About half of all cancer patients suffer from cachexia, which impairs quality of life, limits cancer therapy and decreases survival. One key characteristic of cachexia is el...

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Detalhes bibliográficos
Publicado no:Nature
Main Authors: Kir, Serkan, White, James P., Kleiner, Sandra, Kazak, Lawrence, Cohen, Paul, Baracos, Vickie E., Spiegelman, Bruce M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4224962/
https://ncbi.nlm.nih.gov/pubmed/25043053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13528
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